Androgens and the masculinization programming window: human–rodent differences
نویسندگان
چکیده
منابع مشابه
Experimentally induced testicular dysgenesis syndrome originates in the masculinization programming window.
The testicular dysgenesis syndrome (TDS) hypothesis, which proposes that common reproductive disorders of newborn and adult human males may have a common fetal origin, is largely untested. We tested this hypothesis using a rat model involving gestational exposure to dibutyl phthalate (DBP), which suppresses testosterone production by the fetal testis. We evaluated if induction of TDS via testos...
متن کاملInter-Relationship between Testicular Dysgenesis and Leydig Cell Function in the Masculinization Programming Window in the Rat
The testicular dysgenesis syndrome (TDS) hypothesis proposes that maldevelopment of the testis, irrespective of cause, leads to malfunction of the somatic (Leydig, Sertoli) cells and consequent downstream TDS disorders. Studies in rats exposed in utero to di(n-butyl) phthalate (DBP) have strongly supported the TDS concept, but so far no direct evidence has been produced that links dysgenesis pe...
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Studies involving the administration of anti-androgens to spotted hyaenas during fetal development have raised questions concerning the precise contributions of steroids to phallic growth in these animals. If gonadal androgens promote postnatal penile growth in males, the following would be expected: (a) a period of accelerated growth accompanying achievement of puberty, and (b) a marked reduct...
متن کاملIdentification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism.
Becoming a phenotypic male is ultimately determined by androgen-induced masculinization. Disorders of fetal masculinization, resulting in hypospadias or cryptorchidism, are common, but their cause remains unclear. Together with the adult-onset disorders low sperm count and testicular cancer, they can constitute a testicular dysgenesis syndrome (TDS). Although masculinization is well studied, no...
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Natural disasters, such as earthquakes, tsunamis, and hurricanes cause enormous harm during each year. To reduce casualties and economic losses in the response phase, rescue units must be allocated and scheduled efficiently, such that it is a key issues in emergency response. In this paper, a multi-objective mix integer nonlinear programming model (MOMINLP) is proposed to minimize sum of weight...
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ژورنال
عنوان ژورنال: Biochemical Society Transactions
سال: 2020
ISSN: 0300-5127,1470-8752
DOI: 10.1042/bst20200200